Porcine plasma-derived extracellular vesicles orchestrate multi-target neuroimmune reconfiguration to alleviate Alzheimer's disease pathology in a 5×FAD mouse model - PubMed
3 hours ago
- #Alzheimer's disease
- #Neuroimmunology
- #Extracellular vesicles
- PpSEVs can penetrate the blood-brain barrier and accumulate in the hippocampus of Alzheimer's disease (AD) mouse models.
- They reverse AD pathology by reprogramming the neuroimmune network, reducing microglial pyroptosis and enhancing amyloid-beta clearance.
- PpSEVs also modulate reactive astrocytes, decrease neurotoxic C3, and increase neuroprotective S100A10, while directly activating neuronal BDNF signaling to restore synaptic function.
- This study demonstrates the cross-species therapeutic potential of porcine plasma-derived extracellular vesicles as a scalable, multi-target approach for AD without immunotoxicity.