The V-ATPase/ATG16L1 axis drives membrane remodeling during epithelial morphogenesis - PubMed
3 hours ago
- #membrane remodeling
- #autophagy
- #epithelial morphogenesis
- The study investigates the role of noncanonical autophagy, specifically the V-ATPase/ATG16L1-dependent CASM pathway, in epithelial tubulogenesis during secondary neurulation.
- CASM is essential for lumen resolution in epithelial tubes, coordinating junctional remodeling, phosphoinositide transitions, and Rab-dependent endocytic/recycling pathways for single-lumen formation.
- Findings reveal that noncanonical autophagy acts as a spatially restricted membrane-remodeling mechanism in development, with autophagy pathways contributing hierarchically and in balance.