Akt-mediated RALY phosphorylation functions as a molecular switch governing c-Myc stability - PubMed
3 hours ago
- #Cancer therapy
- #Akt phosphorylation
- #c-Myc stability
- RALY stabilizes c-Myc by bridging USP22 to prevent its ubiquitination and degradation.
- Akt phosphorylates RALY at S106 and T160, enabling complex formation with USP22 and c-Myc to promote its stabilization.
- A RAMi peptide disrupts the RALY-USP22-c-Myc complex, destabilizes c-Myc, and shows anti-tumor effects.