Beyond Inflammation: The Role of Oxidative Stress and Gut-Skin Axis Dysbiosis in the Pathogenesis of Immune-Mediated Skin Disorders and Potential Therapeutic Implications - PubMed
4 hours ago
- #gut-skin axis
- #oxidative stress
- #immune-mediated dermatoses
- Oxidative stress, evidenced by biomarkers like MDA, AGEs, AOPPs, and 8-OHdG, along with reduced antioxidant capacity, contributes to the pathogenesis of immune-mediated skin diseases.
- Ferroptosis, an iron-dependent cell death pathway, driven by lipid peroxidation and GPX4 dysfunction, plays a key role in conditions such as psoriasis and atopic dermatitis.
- Gut-skin axis dysbiosis, characterized by depletion of SCFA-producing bacteria (e.g., Faecalibacterium prausnitzii, Bifidobacterium, Akkermansia muciniphila), disrupts immune homeostasis and barrier function.
- The interplay between oxidative stress, microbiome imbalance, and immune activation involves mechanisms like barrier disruption and modulation of redox signaling by microbial metabolites.
- Emerging therapies targeting these pathways show promise, and integrating redox and microbial profiling could lead to more personalized treatments beyond conventional approaches.