Predicting clinical remission in biologic-treated severe asthma: development of a practical scoring system from a Japanese multicentre study - PubMed
7 hours ago
- #severe asthma
- #clinical remission
- #biologic treatment
- Development of a practical scoring system (MAC score) to predict clinical remission (CR) in biologic-treated severe asthma.
- Study involved 281 patients in the exploratory cohort and 53 in the validation cohort, with CR rates of 37.7% and 35.9% respectively.
- Key predictors for CR identified: male sex (OR 2.34), ACT score ≥20 (OR 3.75), and comorbid chronic rhinosinusitis (CRS) (OR 3.27).
- MAC score assigns 1 point each for male sex (M), ACT ≥20 (A), and CRS (C), showing good discrimination (AUC 0.73 in exploratory, 0.76 in validation).
- MAC score is a simple, interview-based tool applicable across various healthcare settings.