Combined associations of GLP-1 receptor agonists and a healthy lifestyle with cardiovascular outcomes among individuals with type 2 diabetes: a prospective cohort study - PubMed
5 hours ago
- #lifestyle medicine
- #cardiovascular health
- #type 2 diabetes
- Study examines combined effects of GLP-1 receptor agonists and healthy lifestyle on cardiovascular outcomes in type 2 diabetes patients.
- Prospective cohort study of 98,261 US veterans with type 2 diabetes, no prior major cardiovascular events or advanced kidney disease.
- Eight low-risk lifestyle habits assessed: quality diet, physical activity, non-smoking, restful sleep, no heavy alcohol, stress management, social connection, no opioid use.
- Participants adhering to all eight lifestyle habits had 60% lower risk of major adverse cardiovascular events (MACE) compared to those with ≤1 habit.
- GLP-1 receptor agonist users had 16% lower MACE risk compared to non-users.
- Combination of GLP-1 agonists and 6-8 healthy lifestyle factors showed 43% lower MACE risk versus poor lifestyle and no medication.
- Findings highlight importance of combining lifestyle modification with pharmacotherapy in type 2 diabetes management.