Preoperative ctDNA Predicts Upstaging and Recurrence in High-Risk Non-Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy - PubMed
6 hours ago
- #ctDNA
- #Radical Cystectomy
- #Bladder Cancer
- Preoperative ctDNA status predicts recurrence-free survival (RFS) and disease upstaging in high-risk NMIBC patients undergoing radical cystectomy (RC).
- Detectable pre-RC ctDNA was associated with higher rates of upstaging (66.7% vs. 13.3%) and lymph node metastasis (33.3% vs. 0%).
- Patients with undetectable ctDNA had better outcomes, including 20% pT0 and no ≥pT3 or pN+ disease.
- Detectable pre-RC ctDNA showed worse RFS (6-month RFS: 64.3% vs. 100%; 12-month RFS: 38.6% vs. 95.7%).
- Molecular residual disease (MRD) ctDNA post-RC was also linked to worse RFS (HR=14.1).
- The study highlights ctDNA as a potential biomarker for predicting outcomes in high-risk NMIBC.