DNA Methylation Stochasticity is Linked to Transcriptional Variability and Convergent Epigenetic Disruption Across Genetic Subtypes of Acute Myeloid Leukemia - PubMed
6 hours ago
- #Epigenetic Disruption
- #Acute Myeloid Leukemia
- #DNA Methylation
- DNA methylation stochasticity is linked to transcriptional variability in AML.
- AML subtypes with CEBPA double mutation and IDH mutations show high methylation entropy.
- A core program of epigenetic disruption is common across all AML subtypes.
- Methylation entropy reduction observed in IDH2-mutant AML cells treated with decitabine.
- Study connects specific genetic mutations to epigenetic and transcriptional disruption in AML.