Phase separation of β-catenin assembles active loop hubs in colorectal cancer - PubMed
6 hours ago
- #phase-separation
- #colorectal-cancer
- #β-catenin
- β-catenin forms phase-separated condensates in colorectal cancer, assembling active loop hubs.
- These loop hubs are marked by active transcription, elevated gene expression, and H3K4me3 enrichment.
- Disruption of loop hub formation via artificial DNA methylation suppresses gene expression and cancer growth.
- FUS acts as a structural scaffold for β-catenin condensates, while PARP1 maintains active transcription via H3K4me3.
- Depletion of FUS or PARP1 attenuates condensate function through distinct regulatory mechanisms.
- The study links phase separation, genome organization, and cancer progression mechanistically.