Longitudinal plasma metabolomics reveals a role for taurine in asymptomatic malaria and seasonal persistence - PubMed
4 days ago
- #malaria
- #taurine
- #metabolomics
- Longitudinal plasma metabolomics study in the Gambia reveals seasonal changes in the metabolome linked to malaria transmission.
- Taurine levels increase during low malaria transmission periods and inhibit infected red blood cell adhesion to receptors like CD36 and endothelial protein C receptor.
- Taurine does not affect parasite development in vitro but reduces cytoadhesion, potentially mitigating symptomatic malaria.
- Findings suggest taurine could inform strategies to reduce symptomatic malaria in sub-Saharan Africa.