Pharmacological activation of WASp potentiates macrophage phagocytosis and enhances ibrutinib efficacy against mouse models of brain tumors - PubMed
5 hours ago
- #Macrophage Phagocytosis
- #Ibrutinib Enhancement
- #Brain Tumors
- Ibrutinib suppresses brain tumor growth but impairs TAM phagocytosis by disrupting BTK-mediated WASp activation.
- EG-011, a WASp activator, restores phagocytic function and enhances ibrutinib efficacy in mouse brain tumor models.
- Elevated phosphorylated BTK and WASp in TAMs correlate with better patient survival in glioblastoma, highlighting a therapeutic target.