Integrating spatial and single-cell transcriptomics analysis reveals MYCN-UBE2C-TFRC signaling endows ferroptosis resistance in neuroectodermal tumors - PubMed
6 hours ago
- #ferroptosis
- #UBE2C
- #MYCN
- MYCN amplification in neuroectodermal tumors causes resistance to ferroptosis, a type of cell death.
- UBE2C is identified as a key gene activated by MYCN, promoting tumor growth in lab and animal studies.
- UBE2C leads to the degradation of TFRC via ubiquitination, reducing iron uptake and protecting cells from ferroptosis.
- Blocking UBE2C makes tumor cells more susceptible to ferroptosis and enhances the effect of the drug erastin.
- The study suggests targeting the MYCN-UBE2C-TFRC pathway could be a new treatment strategy for these tumors.