Shp1 phosphatase regulates CXCR2 protein stability and IL8-mediated invasiveness in breast cancer - PubMed
12 hours ago
- #Shp1 phosphatase
- #breast cancer
- #CXCR2
- Shp1 phosphatase regulates CXCR2 protein stability and IL8-mediated invasiveness in breast cancer.
- Inhibition of Shp1 in breast cancer cells accelerates cell migration and promotes a more invasive phenotype.
- IL8 modulates Shp1 activity, affecting CXCR2 receptor trafficking and signaling pathways.
- Shp1-mediated regulation of CXCR2 influences IL8-driven invasiveness in luminal and triple-negative breast cancer (TNBC) cells but not HER2-positive ones.
- Downregulation of Shp1 in TNBC correlates with reduced survival and higher IL8 levels.
- Shp1 is identified as a promising therapeutic target to limit invasiveness and metastasis in aggressive breast cancer subtypes, particularly TNBC.