Activation of microglial PPARγ by asperosaponin VI alleviates stress-induced depression and synaptic impairment - PubMed
5 hours ago
- #PPARγ
- #Neuroinflammation
- #Microglia
- Asperosaponin VI (ASA-VI) was identified as a novel natural PPARγ agonist capable of targeting brain microglia.
- ASA-VI promotes PPARγ nuclear translocation in microglia, driving them toward a neuroprotective phenotype and inhibiting neuroinflammation.
- In a chronic stress-induced depression model, ASA-VI improved hippocampal synaptic impairment and depressive-like behaviors.
- Conditional knockout of PPARγ in microglia abolished the therapeutic effects of ASA-VI, confirming its mechanism through microglial PPARγ activation.