Semaglutide attenuates autistic-like behaviors in BTBR mice through the shaping of gut microbiota - PubMed
5 hours ago
- #Semaglutide
- #Autism Spectrum Disorder
- #Gut-Brain Axis
- Semaglutide improves autistic-like behaviors in BTBR mice by modulating gut microbiota.
- The study links gut dysbiosis and metabolic disruptions to autism spectrum disorder (ASD).
- Semaglutide administration enhances social behavior, cognitive function, and reduces repetitive behaviors in BTBR mice.
- Fecal microbiota transplantation from treated mice ameliorates ASD behaviors, indicating gut microbiota's role.
- Adrenic acid (AdA) levels, initially low in BTBR mice, normalize post-semaglutide treatment, influencing behavior.
- Hippocampal neurogenesis is associated with semaglutide treatment, with AdA supplementation restoring social behaviors.
- The findings suggest targeting the gut microbiota-brain axis and AdA as a therapeutic strategy for ASD.