The aging cornea: From mechanisms to clinical applications - PubMed

7 hours ago

Aging is a multifactorial process leading to functional decline and increased disease susceptibility.
The cornea undergoes structural and functional changes with aging, increasing risk for ocular surface diseases.
Key age-related corneal changes include epithelial thinning, stromal remodeling, endothelial cell loss, and reduced nerve density.
Core aging mechanisms affecting the cornea include genomic instability, telomere shortening, mitochondrial dysfunction, and cellular senescence.
Other contributing factors are impaired autophagy, stem cell exhaustion, and chronic inflammation.
The review discusses clinical manifestations, molecular mechanisms, and potential therapies for corneal aging.
Aims to provide a basis for delaying corneal aging and preserving visual function.

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