Fungaemia Caused by the Rare Yeast Starmerella sorbosivorans: A Case Report with Identification via Molecular Phylogenetic Analysis and MALDI-TOF MS - PubMed
4 days ago
- #Catheter-related bloodstream infection
- #MALDI-TOF mass spectrometry
- #Starmerella sorbosivorans
- First documented case of Starmerella sorbosivorans bloodstream infection in a 39-year-old man with chronic intestinal pseudo-obstruction.
- Initial biochemical identification suggested S. magnoliae, but MALDI-TOF MS failed to provide a definitive identification.
- Molecular phylogenetic analysis and MALDI-TOF MS confirmed the isolate as S. sorbosivorans despite low ITS sequence similarity (91.3%) to the type strain.
- Patient successfully treated with micafungin and liposomal amphotericin B, along with catheter removal.
- Antifungal susceptibility testing revealed low MICs for micafungin, amphotericin B, and voriconazole, but high MICs for fluconazole.
- Emphasizes the importance of multilocus sequence analysis for accurate species identification in rare yeast infections.
- Suggests expanding the MALDI-TOF MS reference library to include rare and emerging yeast species.