Huanglian muxiang decoction alleviates FTH-mediated ferroptosis in colitis by inhibiting the PI3K-AKT pathway - PubMed
6 hours ago
- #ferroptosis
- #ulcerative colitis
- #traditional Chinese medicine
- Huanglian muxiang decoction (HMD) alleviates colitis symptoms and improves intestinal integrity in a mouse model.
- HMD regulates iron metabolism and inhibits ferroptosis via the PI3K-AKT pathway, increasing levels of GPX4 and FTH proteins.
- Intestinal-specific knockout of FTH worsens colitis and reduces HMD's protective effects, confirming FTH as a key mediator.
- Active compounds in HMD include alkaloids, flavonoids, and phenylpropanoids, identified through UHPLC-HRMS.
- The study suggests HMD as a potential natural remedy for ulcerative colitis by targeting the PI3K-AKT-FTH axis.