Chloride channel accessory 4 suppresses stem cell-like properties of colorectal cancer and enhances anti-PD-1 immunotherapy - PubMed
3 months ago
- #Immunotherapy
- #Colorectal Cancer
- #CLCA4
- Reduced CLCA4 levels are linked to cancer development and its role in cancer stem cells (CSCs) was explored.
- Decreased CLCA4 expression was found in CD133+CD44+ colorectal CSCs and chemoresistant CRC cells.
- Increased CLCA4 expression inhibited stemness genes, reduced tumorsphere formation, and suppressed self-renewal, migration, and invasion of colorectal CSCs.
- CLCA4 interacted with vimentin, leading to FAK pathway inactivation and suppression of CSC expansion.
- Decreased CLCA4 expression correlated with colorectal CSC markers and vimentin in clinical specimens.
- Increased CLCA4 expression promoted cytotoxic CD8+ T cell infiltration and enhanced anti-PD-1 therapy efficacy.
- CLCA4 may impede colorectal CSC self-renewal by suppressing the FAK signaling pathway, offering new intervention perspectives for CRC.