Expanding the Morphological, Immunohistochemical, and Molecular Spectrums of NUT Carcinoma at Rare Sites of Head and Neck Region - PubMed
5 hours ago
- #NUT carcinoma
- #head and neck cancer
- #molecular pathology
- Study focuses on expanding the understanding of head and neck NUT carcinoma (HN-NC) at rare sites.
- Fifteen HN-NC cases were analyzed, with most found in major salivary glands and oral mucosa.
- Unusual morphologies observed included differentiated papillary squamous cell carcinoma, myoepithelial carcinoma, and small round cell malignancy.
- Molecular analysis revealed BRD4::NUTM1 fusion in most cases, with rare fusions like ZNF532::NUTM1 and novel CCNT2::NUTM1.
- Immunohistochemical markers such as SOX2, PRAME, c-MYC, and EGFR were positive in about half of the cases.
- Prognosis was poor, with tumor site and fusion gene type significantly affecting survival rates.
- HN-NC should be considered in differential diagnoses of poorly differentiated malignancies in the head and neck region.