Muscle Weakness and the Irisin-BDNF and Oxidative Stress Axis in the 60-Day Pseudorandomised Controlled AGBRESA Bed Rest Study - PubMed
5 hours ago
- #muscle atrophy
- #oxidative stress
- #artificial gravity
- The AGBRESA bed rest study examined muscle weakness and the irisin-BDNF and oxidative stress axis over 60 days.
- Participants included 16 men and 8 women, divided into control and artificial gravity (AG) groups to assess disuse effects.
- Bed rest (BR) led to significant reductions in peak torque during knee extension and flexion, with greater losses in women.
- AG attenuated some BR-induced changes in muscle contractile properties but did not affect systemic oxidative stress or irisin levels.
- Higher serum irisin and BDNF levels correlated with lower oxidative stress markers, suggesting a protective role.
- The study concluded that oxidative stress was not the primary contributor to BR-induced muscle strength loss.