AI-MIRACLE: Artificial Intelligence and MultIpaRAmetric MRI Predict CLinical OutcomEs to Neoadjuvant Immunotherapy in Patients with Muscle-invasive Bladder Cancer Undergoing Radical Cystectomy - PubMe
4 hours ago
- #Artificial Intelligence
- #MRI Radiomics
- #Bladder Cancer
- The study AI-MIRACLE developed AI and mpMRI models to predict response to neoadjuvant immunotherapy (pembrolizumab) in muscle-invasive bladder cancer patients.
- Predictive models using post-treatment MRI achieved high accuracy (AUC 0.96 for major response and 0.86 for complete response), outperforming clinical predictors.
- Findings suggest noninvasive imaging biomarkers, like shape-based radiomics and DCE-derived features, could aid in treatment assessment and bladder-preserving decisions.