DS96432529 enhances osteogenic differentiation and mitigates inflammatory damage in periodontal ligament stem cells involving mitophagy-related processes - PubMed
5 hours ago
- #osteogenesis
- #mitophagy
- #periodontitis
- DS96432529 (DS) enhances osteogenic differentiation in periodontal ligament stem cells (PDLSCs).
- DS mitigates inflammatory damage in PDLSCs, particularly under TNF-α-induced conditions.
- DS upregulates mitophagy-related proteins and suppresses the RIG-I-mediated RLR signaling pathway.
- Mitophagy inhibition reduces DS's beneficial effects on osteogenic differentiation under inflammation.
- DS alleviates alveolar bone loss in a rat periodontitis model.
- DS shows potential as a therapeutic molecule for periodontitis-induced bone loss.