Chemoradiation Reprograms Tumor Cells and the Immune Microenvironment in Cervical Cancer - PubMed
5 hours ago
- #chemoradiotherapy
- #cervical cancer
- #MDM2 inhibition
- Cervical cancer remains a leading cause of cancer-related deaths despite advances in screening and prevention.
- A multicohort longitudinal study analyzed human cervical tumors and the tumor microenvironment during chemoradiotherapy (CRT).
- RNA sequencing and single-cell transcriptomics identified cellular and molecular programs affected by CRT.
- MDM2 was identified as a key mediator of radiation responses in tumor and immune cells.
- MDM2 inhibition enhanced radiotherapy effects in HPV-positive, TP53 wild-type cervical cancer cells.
- Combining MDM2 inhibition with CRT could overcome resistance and improve patient outcomes.
- The study provides insights into therapy-induced changes in tumor and immune compartments.
- Findings could guide improved strategies against treatment-resistant HPV-positive cancers.