Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample - PubMed
5 hours ago
- #Amyloid Pathology
- #Sex Differences
- #Alzheimer Disease
- Study examines sex and racial disparities in Alzheimer disease through autopsy data.
- Female individuals showed higher neuritic plaque burden compared to males.
- APOEε4 carriers had a 4-fold greater odds of plaques, regardless of sex.
- Black noncarriers and those of African ancestry had lower plaque burden.
- Female sex, APOEε4, race, and ancestry jointly influence amyloid pathology.
- Findings suggest incorporating sex, race, and ancestry in Alzheimer research and trials.