IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation - PubMed
5 hours ago
- #ADAM17
- #IL-17RA
- #Paneth cells
- IL-17RA signaling is crucial for Paneth cell dedifferentiation into stem-like cells to regenerate gut epithelium post-irradiation.
- Paneth cell-specific IL-17RA knockout mice (Il17rafl/fl;Defa6-cre) show impaired intestinal regeneration, linked to reduced ADAM17 expression.
- ADAM17 overexpression in IL-17RA-deficient mice rescues epithelial regeneration defects, highlighting its role in the IL-17RA-ADAM17 pathway.
- IL-17A induces Nox1 in Paneth cells, leading to H2O2 production, which activates ADAM17 enzymatic activity.
- Paneth cell-specific ADAM17 knockout mice (Adam17fl/fl;Defa6-cre) confirm ADAM17's necessity for tissue regeneration.