Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue - PubMed
5 hours ago
- #microbiome therapy
- #obesity-hypertension link
- #gut microbiome
- Obesity and hypertension are interrelated global health issues with shared mechanisms like insulin resistance, chronic inflammation, and neurohormonal dysregulation.
- The gut microbiome plays a key role by influencing intestinal barrier integrity, systemic inflammation, and metabolic homeostasis, where dysbiosis can lead to increased bacterial product translocation and exacerbate conditions.
- Current treatments for obesity, including lifestyle changes and bariatric surgery, benefit blood pressure, but microbiome-targeted interventions like prebiotics, probiotics, synbiotics, and fecal microbiota transplantation show promise as antihypertensive therapies.
- Research gaps include heterogeneous findings in microbiome studies, the need for larger randomized trials, and advanced microbial sampling techniques beyond fecal analysis to better understand microbiota alterations.