The Hippo Pathway is Dysregulated in Cancer-Associated Fibroblasts in Anti-PD-L1 Resistant Cancer - PubMed
12 hours ago
- #Cancer-Associated Fibroblasts
- #Immunotherapy Resistance
- #Hippo Pathway
- The Hippo pathway is dysregulated in cancer-associated fibroblasts (CAFs) in anti-PD-L1 resistant cancers.
- Study analyzed RNA-sequencing data from 2800 bladder cancer patients and single-cell data from 200 samples.
- Hippo dysregulation in stromal cells, not cancer cells, drives high YAP/TAZ signals in resistant tumors.
- Hippo signaling is specifically altered in CAFs compared to healthy donor fibroblasts.
- Inhibition of YAP signaling with a pan-TEAD inhibitor reduced myofibroblast gene expression and CAF contractility.
- Findings could help develop therapeutic combinations to improve immune checkpoint inhibitor outcomes.