MARCHF6 orchestrates hepatic lipid homeostasis by targeting SREBP1 for ER-associated degradation - PubMed
3 hours ago
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- #SREBP1
- MARCHF6 regulates hepatic lipid homeostasis by targeting SREBP1 for ER-associated degradation, impacting MASLD.
- Hepatic MARCHF6 expression is reduced in MASLD models and patients, and its deletion worsens steatosis, fibrosis, and inflammation.
- MARCHF6 directly ubiquitinates SREBP1, promoting its proteasomal degradation; loss of MARCHF6 increases SREBP1 stability and de novo lipogenesis.
- Restoration of MARCHF6 reverses hepatic steatosis, identifying it as a potential therapeutic target for MASLD intervention.