The exercise hormone irisin has neuroprotective effects in a mouse model of multiple sclerosis - PubMed
3 hours ago
- #neuroprotection
- #exercise
- #multiple sclerosis
- Irisin, an exercise hormone, shows neuroprotective effects in a mouse model of multiple sclerosis (MS).
- Voluntary exercise protects against inflammation-induced neurodegeneration in experimental autoimmune encephalomyelitis (EAE) mice, but this protection is lost in mice lacking irisin.
- Peripheral administration of irisin reduces clinical symptoms and neuronal loss in EAE mice, without affecting immune responses.
- Irisin induces a direct neuroprotective gene program in spinal cord neurons, preserving synapses and mitochondrial activity.
- The findings suggest irisin could be a therapeutic candidate for MS, leveraging exercise-derived protective mechanisms.
- The study is supported by multiple NIH grants, and authors have noted conflicts of interest related to irisin patents and therapeutic developments.