Rethinking prognosis in multiple sclerosis: a multiaxial perspective - PubMed
2 hours ago
- #multiaxial model
- #prognosis
- #multiple sclerosis
- Multiple sclerosis (MS) prognosis remains uncertain despite treatment advances.
- Current prognostic models focus on disease burden but overlook compensatory mechanisms.
- A multiaxial model is proposed, covering damage burden, injury topography, and compensation capacity.
- Tools for assessment include clinical exams, MRI, biofluid markers, OCT, and digital monitoring.
- The MAGNIMS consortium provides a non-prescriptive framework for personalized risk prediction.
- The work is a conceptual roadmap for future research, not a clinical guideline.