Mitochondrial quality in aging and neurodegeneration: The emerging role of mitochondria-derived vesicles - PubMed
5 days ago
- #aging
- #mitochondria
- #neurodegeneration
- Mitochondria play a key role in cellular energy metabolism, redox balance, and signaling.
- Mitochondrial quality control (MQC) includes proteostasis, dynamics, biogenesis, and mitophagy to maintain mitochondrial integrity.
- Mitochondria-derived vesicles (MDVs) are a newly identified component of MQC, transporting damaged components to endolysosomal compartments.
- MDVs act upstream of or in parallel with mitophagy to prevent irreversible mitochondrial damage.
- Aging and neurodegenerative diseases are linked to mitochondrial dysfunction and chronic inflammation.
- Age-related changes may impair MDV formation, cargo selection, and targeting, affecting cellular homeostasis.
- Defective degradation can lead to mitochondrial components appearing in extracellular vesicles, potentially contributing to inflammation.
- Neurons are particularly vulnerable to mitochondrial dysfunction due to high energy demands and tight turnover regulation.
- The review discusses implications for biomarkers and therapeutic strategies in neurodegeneration.