G-Quadruplex-Modular CpG Nanoplatform Drives Multi-Pathway Immunity for Abscopal Chemoimmunotherapy - PubMed
8 hours ago
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- #abscopal effect
- #nanoplatform
- A G-quadruplex-modular CpG nanoplatform called IONP-G4-DOX/IMT was developed to enhance cancer immunotherapy by addressing challenges like insufficient immune activation and CpG degradation.
- The nanoplatform utilizes iron oxide nanoparticles as a core and a G4 module to provide nuclease resistance for CpG, load doxorubicin for immunogenic cell death, and anchor IMT to activate the cGAS-STING pathway.
- In murine breast cancer models, it achieved a 79.4% primary tumor suppression rate and induced long-term antitumor immunity, including inhibition of contralateral tumor growth, without significant systemic toxicity.