Lesion Site-Targeted Microspheres Modulate Nav1.7-Related Signaling for Osteoarthritis Treatment - PubMed
4 hours ago
- #Osteoarthritis
- #Nav1.7 Signaling
- #Drug Delivery
- Developed acid-responsive, cartilage-targeted microspheres (CBZ/WCOM) for sustained drug delivery in osteoarthritis treatment.
- CBZ/WCOM attenuated inflammation and catabolic markers in chondrocytes, while partially restoring anabolic markers.
- Modulated Nav1.7-related signaling, affecting sodium currents and calcium dynamics in chondrocytes.
- In a mouse model, CBZ/WCOM improved pain thresholds, reduced neural remodeling, and preserved joint structure.
- WYRGRL peptide enables targeting to type II collagen, supporting localized drug retention for minimally invasive therapy.