Unraveling the toxicological impact of Bisphenol A exposure on dermatomyositis: An integration of network toxicology and machine learning approaches - PubMed
6 hours ago
- #Bisphenol A
- #Dermatomyositis
- #Network Toxicology
- Bisphenol A (BPA) exposure shows toxicity including neurotoxicity, nephrotoxicity, hepatotoxicity, skin sensitization, and immunotoxicity, potentially contributing to dermatomyositis.
- Network toxicology and machine learning identified SAA1, NACAD, SLC14A1, and MYBPH as core genes in dermatomyositis, with SAA1 having the strongest binding affinity to BPA.
- BPA may influence dermatomyositis via pathways like apoptosis, immune-inflammatory responses, and PI3K-Akt signaling, highlighting SAA1 as a key target for further research.