Insulin resistance induced by pesticides is overcome by pancreatic islet adaptation in a mouse model of Parkinson's disease - PubMed
2 hours ago
- #pancreatic islets
- #pesticides
- #insulin resistance
- Pesticide exposure links to type 2 diabetes and Parkinson's disease, with a mouse study exploring the mechanisms.
- Chronic low-dose pesticide exposure caused body weight gain and insulin resistance in both wild-type and Parkinson's model mice.
- Parkinson's model mice (M83) developed early motor deficits and brain insulin resistance from pesticide exposure.
- Surprisingly, M83 mice showed improved glucose tolerance and increased pancreatic beta-cell mass and function.
- Transcriptomic analysis revealed enriched amino-acid metabolism genes in M83 islets with high α-synuclein expression.
- α-synuclein may play a key role in beta-cell adaptation to overcome pesticide-induced insulin resistance.