Conditional BCL-2 Expression in Fibroblasts Promotes Persistent Pulmonary Fibrosis which is Reversible by Therapeutic BCL-2 Inhibition - PubMed
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- #fibroblasts
- #pulmonary fibrosis
- #BCL-2
- Conditional BCL-2 expression in fibroblasts leads to persistent pulmonary fibrosis by preventing apoptosis of PDGFRα+ fibroblasts.
- Senescent, pro-fibrotic fibroblasts accumulate in fibrotic regions, contributing to pathologic lung remodeling.
- Spatial transcriptomic studies confirm the presence of senescent, BCL-2 expressing myofibroblasts in human IPF lungs.
- Selective BCL-2 inhibition with ABT-199 promotes apoptosis in fibroblasts, reduces senescence, and reverses fibrosis in mice.
- BCL-2 expression in fibroblasts is a therapeutically relevant target for reversing persistent pulmonary fibrosis.