The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons - PubMed
18 hours ago
- #Proteostasis
- #Autophagy
- #NatB
- NatB, an N-terminal acetyltransferase, acetylates approximately 20% of eukaryotic proteomes.
- CRISPR-Cas9 deletion of NatB in plants reduces global protein turnover by lowering UPS activity and protein translation.
- NatB substrates are enriched among stabilized proteins in natb mutants, indicating protection from degradation.
- Absent NTA of KIN11 (SnRK1 subunit) shields it from UPS destruction, leading to its accumulation.
- Accumulated KIN11 enhances natb mutant resistance to energy limitation, such as prolonged darkness.
- NatB acts as a key regulator of UPS-autophagy interplay, maintaining proteome stability and stress response in plants.