Lipid oxidation reprogramming in cancer-associated fibroblasts enhances CD8+ T cell cytotoxicity and therapeutic response - PubMed
8 days ago
- #lipid oxidation
- #cancer-associated fibroblasts
- #CD8+ T cell immunity
- Lipid oxidation reprogramming in cancer-associated fibroblasts (CAFs) enhances CD8+ T cell cytotoxicity and therapeutic response.
- A chemotherapy-conditioned PTGER3+ CAF subset with enhanced lipid oxidation promotes CD8+ T cell activation and cytotoxicity by suppressing PTEN-related signaling.
- Higher proportions of therapy-induced PTGER3+ CAFs correlate with improved treatment responses and better patient prognosis.
- The findings highlight CAF-driven lipid oxidation and its regulation of CD8+ T cell PTEN signaling as potential avenues to enhance chemotherapy and immunotherapy efficacy.