Per- and Polyfluoroalkyl Substances in Umbilical Cord Serum and Key Intermediate Metabolites in Relation to Preterm Birth: A Multicenter Case-Control Study - PubMed
5 hours ago
- #PFAS
- #metabolomics
- #preterm birth
- Study examines prenatal PFAS exposure and preterm birth (PTB) risk in Chinese populations.
- Higher PFAS levels in umbilical cord serum linked to increased PTB risk, with PFTrDA showing the strongest association.
- PFAS mixtures had a positive joint effect on PTB risk.
- Metabolomics identified PFTrDA as causing the most metabolic perturbations, with GDCA mediating 21-44% of PFAS-PTB associations.
- Findings suggest disruptions in bile acid and lipid metabolism contribute to PTB risk.