Molecular pathways and emerging therapeutic targets in the pathogenesis of diabetic kidney disease - PubMed
3 days ago
- #therapeutic targets
- #diabetic kidney disease
- #molecular pathways
- Diabetic kidney disease (DKD) arises from intersecting metabolic, hemodynamic, inflammatory, and epigenetic programs.
- Hyperglycemia-driven AGE-RAGE signaling, PKC activation, and RAAS dysregulation lead to oxidative stress, endothelial dysfunction, and profibrotic transcription.
- Mitochondrial and endoplasmic-reticulum stress amplify lipotoxicity and cell death.
- Innate immune activation and maladaptive repair promote extracellular-matrix accumulation and nephron loss.
- Multi-omics studies implicate durable chromatin and non-coding RNA changes that sustain metabolic memory.
- Therapeutic strategies include established agents (RAAS blockade, SGLT2 inhibitors, non-steroidal MR antagonists) and investigational approaches (epigenetic modulators, AMPK/NAD+ axis targeting, gene/RNA-based interventions).
- DKD is framed as a disorder of rewired signaling and gene-regulatory circuitry.