Glucose/ROS-responsive and redox-gated adaptive hydrogel dressing for accelerating diabetic wound repair via synergistic cGAS/STING pathway inhibition and oxidative stress alleviation - PubMed
5 hours ago
- #Hydrogel dressing
- #STING pathway inhibition
- #Diabetic wound healing
- Development of a glucose/ROS-responsive hydrogel dressing (SG) for diabetic wound repair.
- Hydrogel features include injectability, stretchability, self-healing, and adaptability to wound shapes.
- Incorporation of macrophage-targeting liposomes (HPSL) for precise delivery of STING inhibitor H151.
- Hydrogel releases chlorogenic acid (CGA) and HPSL in response to high glucose and ROS levels.
- CGA reduces oxidative stress by scavenging ROS, achieving a 79.9% reduction in superoxide anion levels.
- HPSL targets macrophages to inhibit the STING pathway, reducing pro-inflammatory cytokines (TNF-α, IL-6) and promoting IL-10.
- Enhanced angiogenesis (6.6-fold increase in CD31, 7.3-fold in VEGF) and collagen deposition (32.6% to 69.3%).
- Achieves 89.7% wound recovery in 10 days and nearly complete healing in 14 days.
- Potential clinical application for diabetic wound healing.