Microbiota-driven mechanisms in multisystem diseases: integrative evidence across cardiovascular, metabolic, neurological and autoimmune disorders - PubMed
21 hours ago
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- #dysbiosis
- #microbiota
- The human microbiota is a key biological system involved in metabolic, immunological, and neuroendocrine communication with the host.
- Dysbiosis, or disruption of the microbiota, is a fundamental factor in the onset and progression of chronic diseases across multiple systems.
- Gut-derived metabolites like short-chain fatty acids, bile acids, TMAO, and LPS link microbial imbalance to inflammation, metabolic issues, autoimmunity, and neurodegeneration.
- Dysbiosis contributes to conditions including cardiovascular diseases, metabolic disorders, neurological diseases, and autoimmune disorders.
- Key pathways involve the gut-brain, gut-lung, and gut-kidney axes, enabling bidirectional immune and metabolic signaling between the gut and distant organs.
- Emerging therapeutic interventions aim to restore microbial balance through dietary strategies, probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and microbiome-targeted drugs.
- The microbiota is positioned as a central regulator of health and disease, offering potential for new diagnostic and therapeutic innovations.
- Advancing the understanding of host-microbe interactions is essential for developing personalized microbiome-based strategies to prevent or treat diseases.