Generation of spinal cord organoids from human induced pluripotent stem cells caudalised to a lumbar fate - PubMed
2 days ago
- #Human iPSCs
- #Neurodevelopmental Modeling
- #Spinal Cord Organoids
- Development of spinal cord organoids from human iPSCs patterned to a lumbar fate, showing enriched neuronal populations and diverse glial subtypes.
- Organoids recapitulate ventral spinal cord features with functional neuronal properties, including spontaneous activity and integrated neural networks.
- Provides a physiologically relevant human-specific model for studying spinal cord development, neurodegenerative diseases, and spinal cord injury.