The Role of Innervation in Ocular Surface Homeostasis, Tissue Remodeling Following Nerve Injury, and the Therapeutic Potential of Hemocomponents in Neuronal and Cicatricial Pathologies - PubMed
4 hours ago
- #neurotrophic keratopathy
- #corneal innervation
- #blood-derived eye drops
- The ocular surface functions as a neuro-epithelial-immune unit, with corneal innervation crucial for maintaining tissue integrity and visual function.
- Sensory nerves regulate reflex tearing, blinking, provide trophic support, and modulate local immune responses.
- Nerve injury from trauma, surgery, infection, or chronic inflammation can disrupt epithelial homeostasis, leading to neurotrophic keratopathy, neuropathic pain, and pathological remodeling.
- Nerve dysfunction contributes to severe dry eye and immune-mediated cicatricial disorders, with remodeling leading to stromal thinning or progressive fibrosis.
- Blood-derived eye drops, including serum- and platelet-based formulations, support epithelial repair and nerve regeneration but require greater standardization.