DEHP-induced male reproductive toxicity: Evidence from population studies, animal experiments, and multi-omics profiling - PubMed
3 hours ago
- #multi-omics profiling
- #male reproduction
- #DEHP toxicity
- DEHP exposure is linked to testosterone deficiency in adult men based on NHANES data, with oxidative metabolites showing a monotonic dose-response relationship.
- Animal studies with rats demonstrated that DEHP reduces testosterone, disrupts testicular structure and spermatogenesis, and increases oxidative stress, inflammation, and macrophage infiltration.
- Multi-omics analyses identified hub genes (NNT, ACSS1, NANOG, S100A16, CELF4) involved in mitochondrial energy metabolism and redox homeostasis as key players in DEHP-induced reproductive toxicity.
- Computational screening prioritized ursolic acid as a candidate compound for intervention, showing potential stability in molecular dynamics simulations, though experimental validation is still needed.