Methionine, Homocysteine, and Methylation Levels Predict Cognitive Decline in Alzheimer's Disease - PubMed
3 hours ago
- #Alzheimer's disease
- #biomarkers
- #cognitive decline
- AD patients show lower methionine and methylation levels but higher homocysteine compared to cognitively normal individuals.
- Elevated homocysteine in AD is linked to lower MMSE scores, higher WMH volumes, lower vitamin B12, and older age.
- Low methionine and methylation levels correlate with severe cognitive impairment and brain atrophy in AD.
- Longitudinally, AD patients with unfavorable metabolic profiles experience greater cognitive decline over one year.
- These metabolic and epigenetic factors may serve as biomarkers or therapeutic targets for Alzheimer's disease.