m6A-mediated stabilization of Bhlhe22 suppresses osteogenesis in osteoporosis by activating the PI3K-AKT-GSK3β signaling axis - PubMed
5 hours ago
- #osteoporosis
- #PI3K-AKT-GSK3β
- #m6A modification
- m6A modification stabilizes Bhlhe22 mRNA, leading to its overexpression in osteoporosis (OP).
- Elevated BHLHE22 protein suppresses osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
- BHLHE22 activates the PI3K-AKT-GSK3β signaling axis by transactivating Pik3r3.
- Targeting the m6A-Bhlhe22-PI3K axis could be a therapeutic strategy for osteoporosis.
- Bhlhe22 knockdown restored osteogenic potential in OP-BMSCs and improved bone structure in OVX rats.