Tspan4+ fibroblasts facilitate the development of NECSO in myocardial ischemia reperfusion through migrasomes-mediated Tnf-α autocrine and cardiomyocytes aldosterone generation - PubMed
6 hours ago
- #myocardial ischemia reperfusion
- #NECSO
- #Tspan4 fibroblasts
- Tspan4+ fibroblasts promote NECSO (Necrosis by Sodium Overload) in myocardial ischemia/reperfusion (I/R).
- Sodium ion accumulation in cardiomyocytes under I/R triggers NECSO, influenced by Trpm4 modulation.
- Tspan4 is a core NECSO-related gene expressed in fibroblasts, enhancing NECSO via migrasome-mediated Tnf-α autocrine signaling.
- Migrasomes upregulate Tnf-α in fibroblasts, increasing Cyp11b2 protein and aldosterone synthesis in cardiomyocytes.
- Eplerenone improves prognosis in vivo, suggesting therapeutic potential against NECSO in myocardial I/R injury.