Rbm24 promotes outer hair cell survival through Insm1 repression while independently regulating hair bundle morphogenesis - PubMed
4 hours ago
- #Outer Hair Cell Survival
- #Insm1 Repression
- #Rbm24
- Rbm24 inactivation in cochlear outer hair cells (OHCs) leads to cell death and hair bundle defects.
- Transcriptomic analysis shows Rbm24 loss disrupts hair bundle morphogenesis genes and delays OHC differentiation.
- Insm1, a transcription factor normally downregulated by postnatal day 2 (P2), remains persistently expressed in Rbm24-/- OHCs.
- Overexpression of Insm1 alone causes OHC death, while its inactivation with Rbm24 loss rescues survival but only partially restores hair bundle morphology.
- Rbm24 promotes OHC survival by repressing Insm1 independently of its role in hair bundle morphogenesis.
- Findings position Rbm24 as a dual-function regulator coordinating OHC differentiation and structural maturation.